Aspergillus oryzae peritonitis in CAPD: case report and review of the literature

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Published on: December 18, 2010

Ines Schwetz1, Jörg Horina, Walter Buzina

  • 1Department of Pulmonology, Division of Infectious Diseases, Medical University of Graz, Austria.

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
|May 3, 2007
PubMed

Insights

Fungal peritonitis from Aspergillus oryzae is a serious complication of continuous ambulatory peritoneal dialysis (CAPD). Successful treatment requires antifungal therapy and catheter removal, crucial for patient survival.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Nephrology

Background:

  • Fungal peritonitis is a rare but severe complication associated with continuous ambulatory peritoneal dialysis (CAPD).
  • Aspergillus species are uncommon causes of peritonitis in CAPD patients.

Observation:

  • A case of peritonitis caused by Aspergillus oryzae in a CAPD patient is presented.
  • The causative agent, Aspergillus oryzae, was identified using ribosomal DNA sequence analysis.

Findings:

  • Successful treatment involved a combination of antifungal medications (amphotericin B, caspofungin, itraconazole) and surgical removal of the peritoneal dialysis catheter.
  • A review of 10 reported cases since 2003 indicates a 30% mortality rate for fungal CAPD-related peritonitis.

Implications:

  • Systemic antifungal therapy and removal of the CAPD catheter are critical for achieving clinical cure in fungal peritonitis.
  • This case highlights the importance of accurate fungal identification and aggressive management strategies.

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