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Related Experiment Video

Updated: Jul 15, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

Nutritional deficiencies in celiac disease.

Susan H Barton¹, Darlene G Kelly, Joseph A Murray

¹Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

Gastroenterology Clinics of North America

|May 3, 2007

Summary

Celiac disease involves small intestine damage from gluten in susceptible people. Dietary gluten removal heals the intestine, but reintroduction causes recurring damage and malnutrition.

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Last Updated: Jul 15, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

Area of Science:

Gastroenterology
Immunology
Nutrition Science

Background:

Celiac disease is an autoimmune disorder triggered by gluten ingestion in genetically predisposed individuals.
It manifests as a small bowel enteropathy, leading to intestinal damage.

Observation:

Gluten, found in wheat, rye, and barley, precipitates the condition.
Intestinal healing occurs upon strict gluten elimination from the diet.
Reintroducing gluten leads to recurrent intestinal damage.

Findings:

Celiac disease results in maldigestion and malabsorption.
Malnutrition is a common consequence, though not universally present.
The condition represents a permanent gluten intolerance.

Implications:

Understanding the spectrum of celiac disease is crucial for accurate diagnosis and management.
The impact on nutrition requires careful dietary monitoring and intervention.
Effective management strategies focus on lifelong gluten avoidance and addressing nutritional deficiencies.