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Related Experiment Videos

Intestinal transplantation: current status.

Jonathan P Fryer1

  • 1Division of Transplantation, Department of Surgery, Feinberg School of Medicine, Northwestern University, 675 North St. Clair Street, Galter, Pavilion Suite 17-200, Chicago, IL 60611-2923S, USA. jfryer@nmh.org

Gastroenterology Clinics of North America
|May 3, 2007
PubMed
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Intestine transplants offer improved survival for intestinal failure patients. Consider this surgery earlier for those at high risk of liver complications from long-term parenteral nutrition.

Area of Science:

  • Gastroenterology
  • Transplant Surgery
  • Hepatology

Background:

  • Intestinal failure necessitates parenteral nutrition (PN), which can lead to severe complications like PN-associated liver disease (PNALD).
  • Current practice often delays intestine transplant consideration until PNALD is advanced and liver transplant is also required.

Purpose of the Study:

  • To evaluate the outcomes of intestine transplantation.
  • To advocate for earlier consideration of intestine transplantation in select patients.

Main Methods:

  • Review of outcomes data for intestine transplantation.
  • Comparison of survival rates for intestine-only transplants versus liver transplants.

Main Results:

  • Intestine transplantation outcomes are improving, with 1-year survival rates for intestine-only transplants now comparable to liver transplants.

Related Experiment Videos

  • Delayed transplantation is common, often occurring after severe PNALD develops.

    • Conclusions:

    • Intestine transplantation is a viable option for intestinal failure with improving outcomes.
    • Earlier consideration of intestine transplantation in high-risk patients may prevent severe complications like PNALD and improve overall survival.