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Updated: Jul 15, 2026
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Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy
Published on: June 7, 2015
Frame-based immobilization and targeting for stereotactic body radiation therapy
Bryan Murray1, Kenneth Forster, Robert Timmerman
1Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. bryan.murray@utsouthwestern.edu
Summary
Frame-based stereotactic body radiation therapy (SBRT) with a body frame ensures precise radiation delivery and patient immobilization. This method achieves high local tumor control with minimal side effects, enhancing treatment outcomes.
Area of Science:
- Medical Physics
- Radiation Oncology
- Biotechnology
Background:
- Frame-based stereotactic body radiation therapy (SBRT) offers enhanced precision for extracranial targets.
- Secure patient immobilization is crucial for effective SBRT delivery.
Purpose of the Study:
- To review the optimal use of an extracranial immobilization device for SBRT.
- To detail a 4-step approach for frame-based SBRT.
Main Methods:
- Patient immobilization using a Vac-Loc bag within a body frame.
- Organ and motion control via fluoroscopy and an abdominal pressure plate (< 1 cm diaphragmatic excursion).
- Treatment planning with Philips Pinnacle 6.2b, utilizing noncoplanar beams and inverse optimization, followed by daily CT-based targeting.
Main Results:
- Daily setup variation averaged < 5 mm, comparable to published data.
- Treatment times ranged from 30 to 45 minutes.
- High local control rates with acceptable severe side effects were observed.
Conclusions:
- Frame-based SBRT provides comfortable immobilization and accurate tumor targeting.
- Abdominal compression effectively reduces target and tissue motion.
- SBRT with a body frame enables precise, large-dose-per-fraction treatments for localized tumors, aiming for improved therapeutic results.
