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Related Experiment Videos

Evolution, atmospheric oxygen, and complex disease.

Lauren Gerard Koch1, Steven L Britton

  • 1Functional Genomics Laboratory, Department of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, Michigan, USA.

Physiological Genomics
|May 3, 2007
PubMed
Summary
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Evolutionary biology suggests disease is linked to energy transfer. This study connects complex diseases to the evolution of cellular complexity driven by oxygen, highlighting aerobic capacity

Area of Science:

  • Evolutionary biology
  • Metabolic studies
  • Disease etiology

Background:

  • Disease patterns are closely associated with evolutionary biology.
  • Optimal energy transfer capacity is a key evolutionary pattern.
  • The transition to cellular complexity was influenced by oxygen's thermodynamic properties.

Purpose of the Study:

  • To propose a link between complex disease etiology and the evolutionary shift to cellular complexity.
  • To investigate the role of oxygen metabolism in cellular function and disease.
  • To test the connection between evolution, oxygen metabolism, and complex disease.

Main Methods:

  • Analysis of clinical studies linking aerobic capacity and mortality.
  • Large-scale network analyses of oxygen metabolism.

Related Experiment Videos

  • Artificial selection experiments in rats to study disease risk segregation based on aerobic capacity.

    • Main Results:

    • Clinical data show a strong statistical link between low aerobic capacity and all-cause mortality.
    • Network analyses confirm the central role of oxygen metabolism in cellular function.
    • Artificial selection in rats demonstrated segregation of disease risks with aerobic capacity levels.

    Conclusions:

    • Complex diseases are tightly linked to the evolutionary transition to cellular complexity facilitated by oxygen.
    • Oxygen metabolism is pivotal for cellular function and development of complex life.
    • Aerobic capacity is a significant factor in disease risk and mortality.