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Related Experiment Videos

The effect of blood decrease on (67)Ga uptake by the liver in partially hepatectomized rats.

Yosuke Ohtake1, Akiko Maruko, Satoko Satoh

  • 1Department of Radiopharmacy, Tohoku Pharmaceutical University, Sendai, Miyagi, Japan. y-ohtake@tohoku-pharm.ac.jp

Biological & Pharmaceutical Bulletin
|May 3, 2007
PubMed
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Gallium-67 (67Ga) uptake differs between partial hepatectomy and venesection. Partial hepatectomy increases liver 67Ga uptake, while venesection increases reticulocyte uptake, due to altered transferrin receptor expression.

Area of Science:

  • Nuclear Medicine
  • Physiology
  • Oncology

Background:

  • Gallium-67 (67Ga) binds to transferrin (Tf) and is transported via Tf receptors.
  • Partial hepatectomy (PH) reduces circulating blood volume and Tf.
  • Venesection (VS) also reduces circulating blood volume but not liver tissue.

Purpose of the Study:

  • To investigate the impact of decreased blood volume and Tf on 67Ga uptake in the liver.
  • To compare 67Ga uptake following partial hepatectomy versus venesection.

Main Methods:

  • Rats underwent either two-thirds partial hepatectomy or 2 mL venesection.
  • Rats were intravenously injected with 67Ga.
  • Erythrocyte, reticulocyte, and tissue 67Ga uptake were measured.

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Main Results:

  • Erythrocyte and reticulocyte levels changed similarly after PH and VS.
  • Reticulocyte 67Ga uptake increased significantly after VS, but not PH.
  • Liver 67Ga uptake increased significantly after PH, but not VS.

Conclusions:

  • Differences in 67Ga uptake are linked to altered transferrin receptor expression on the liver post-PH.
  • Partial hepatectomy enhances liver 67Ga uptake, whereas venesection enhances reticulocyte 67Ga uptake.