Inclusion effect and structural basis of cyclodextrins for increased extraction of medicinal alkaloids from natural
Miyoko Kamigauchi1, Kazuko Kawanishi, Hirofumi Ohishi
1Kobe Pharmaceutical University, Motoyama Kitamachi, Kobe, Japan. kamigami@kobepharma-u.ac.jp
Abstract:
The enhancing effects of alpha-, beta-, and gamma-cyclodextrins (CyDs) on the aqueous extraction of ephedrine and berberine from the natural medicines were investigated in HPLC analysis, and the greatest effect was observed for beta- and gamma-CyDs. To clarify the structural basis of such an increased extraction effect with beta-CyD, possible interaction modes of (1R,2S)-ephedrine with alpha-, beta-, and gamma-CyDs were investigated using molecular dynamic simulations in an aqueous solution system. It was shown that the wrapping model of ephedrine by beta-CyD is the most compact and thus increases the solubility most effectively, compared with those by other CyDs. The same mode could be possible for the greatest effect of gamma-CyD on the extraction of berberine from natural medicines. This clearly shows that CyDs are useful additives for the effective extraction of bioactive alkaloids from natural medicines.
More Related Videos
Related Concept Videos
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry
Extraction: Advanced Methods
Factors Influencing Drug Absorption: Physicochemical Parameters
Enhanced drug absorption can be achieved by reducing particle sizes and increasing surface areas, thereby facilitating...
Bioavailability Enhancement: Drug Permeability Enhancement
Hepatic Drug Excretion: Enterohepatic Cycling
Post-release drugs and metabolites can be reabsorbed into the body from the intestine. For conjugated metabolites like glucuronides, reabsorption requires enzymatic hydrolysis by intestinal microflora. This...
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention


