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Updated: Jul 15, 2026

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
Published on: September 9, 2012
Acquired factor V inhibitor responsive to corticosteroids in a patient with double cancers
Hitoshi Endo1, Kiyotaka Kawauchi, Masahiko Tomimatsu
1Department of Internal Medicine, Tokyo Women's Medical University Medical Center East, Tokyo, Japan. endogm@dnh.twmu.ac.jp <endogm@dnh.twmu.ac.jp>
Abstract:
A 70-year-old woman suffering from HCV-related liver cirrhosis was admitted for abnormal bleeding. Laboratory findings included PT at 46.6 sec, APTT at >212 sec, factor V activity of <3%, and factor V inhibitor of 2 BU. Having experienced a persistent bleeding tendency for one month, the patient was started on prednisolone (0.8 mg/kg/day). Within a few days, the inhibitor became undetectable and clinical bleeding disappeared. Although clinical improvement was achieved, she died 6 months after the initial bleeding episode from the progression of a lung cancer. An autopsy revealed squamous cell carcinoma of the lung and hepatocellular carcinoma.
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