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Related Concept Videos

Radiation: Applications01:17

Radiation: Applications

The average temperature of Earth is the subject of much current discussion. Earth is in radiative contact with both the Sun and dark space; it receives almost all its energy from the radiation of the Sun and reflects some of it into outer space. Dark space is very cold, about 3 K, so Earth radiates energy into it. For instance, heat transfer occurs from soil and grasses, the rate of which can be so rapid that frost can occur on clear summer evenings, even in warm latitudes.
The average...

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Voluntary Breath-hold Technique for Reducing Heart Dose in Left Breast Radiotherapy
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Current application and research directions for partial-breast irradiation.

Sharad Goyal1, Thomas Kearney, Bruce G Haffty

  • 1Department of Radiation Oncology, UMDNJ-Robert Wood Johnson, Medical School, New Brunswick, NJ 08903, USA.

Oncology (Williston Park, N.Y.)
|May 4, 2007
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Accelerated partial-breast irradiation (APBI) offers a shorter, convenient alternative to whole-breast irradiation (WBI) for early-stage breast cancer. Early data suggest APBI provides excellent local control with minimal toxicity, though further trials are ongoing.

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Published on: March 11, 2021

Area of Science:

  • Oncology
  • Radiation Oncology
  • Surgical Oncology

Background:

  • Breast-conservation therapy (BCT), including lumpectomy and whole-breast irradiation (WBI), is standard for early-stage breast cancer.
  • Some patients opt for mastectomy or lumpectomy alone due to various factors.
  • Accelerated partial-breast irradiation (APBI) is an alternative radiotherapy approach.

Purpose of the Study:

  • To review the rationale and current data supporting Accelerated partial-breast irradiation (APBI).
  • To discuss various APBI techniques used globally.
  • To compare APBI with Whole-Breast Irradiation (WBI) in early-stage breast cancer treatment.

Main Methods:

  • Review of existing literature and clinical trial data on APBI.
  • Discussion of different radiotherapy techniques for partial breast irradiation.
  • Analysis of outcomes including local control, toxicity, and patient convenience.

Main Results:

  • APBI delivers higher daily radiation doses to the surgical cavity over a shorter period (1-2 weeks) compared to WBI (6-6.5 weeks).
  • Early findings indicate excellent local control and minimal acute toxicity with APBI.
  • Patient convenience is cited as a significant advantage of APBI.

Conclusions:

  • APBI presents a promising, time-efficient alternative to WBI for select early-stage breast cancer patients.
  • Ongoing Phase III trials are crucial for definitive comparison of APBI and WBI regarding long-term outcomes and quality of life.
  • Further research will solidify APBI's role in breast cancer treatment paradigms.