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[Diabetes prevention in hypertensive patients]
X Girerd1, B Hansel, F Villeneuve
1Service d'endocrinologie-métabolisme, unité de prevention cardiovasculaire, hôpital de La Pitié-Salpêtrière. 83, boulevard de l'Hôpital, 75013 Paris. xavier.girerd@psl.aphp.fr
Archives Des Maladies Du Coeur Et Des Vaisseaux
|May 4, 2007
Summary
Certain hypertension medications, like ACE-inhibitors, can delay type-2 diabetes onset. Beta-blockers combined with diuretics may increase diabetes risk in hypertensive patients.
Area of Science:
- Cardiology
- Endocrinology
- Pharmacology
Context:
- Hypertension and type-2 diabetes frequently coexist.
- Managing hypertension offers opportunities to delay type-2 diabetes onset.
Purpose:
- To evaluate the impact of different antihypertensive drug classes on type-2 diabetes incidence.
- To compare the efficacy of renin-angiotensin blockers versus other therapies in preventing diabetes.
Summary:
- Renin-angiotensin blockers (ACE-inhibitors and Angiotensin II antagonists) show a 22% lower incidence of diabetes compared to other treatments.
- Beta-blocker and diuretic combinations are associated with a higher risk of developing type-2 diabetes.
- The ALLHAT trial indicated the lowest diabetes incidence with ACE-inhibitors and the highest with thiazide diuretics.
Impact:
- Findings suggest a potential role for specific antihypertensive agents in diabetes prevention strategies.
- Further research, including NAVIGATOR and ONTARGET trials, is expected to confirm these results and elucidate mechanisms like insulin resistance reduction.
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