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[Diabetes prevention in hypertensive patients]

X Girerd1, B Hansel, F Villeneuve

  • 1Service d'endocrinologie-métabolisme, unité de prevention cardiovasculaire, hôpital de La Pitié-Salpêtrière. 83, boulevard de l'Hôpital, 75013 Paris. xavier.girerd@psl.aphp.fr

Archives Des Maladies Du Coeur Et Des Vaisseaux
|May 4, 2007
PubMed

Insights

Certain hypertension medications, like ACE-inhibitors, can delay type-2 diabetes onset. Beta-blockers combined with diuretics may increase diabetes risk in hypertensive patients.

Area of Science:

  • Cardiology
  • Endocrinology
  • Pharmacology

Context:

  • Hypertension and type-2 diabetes frequently coexist.
  • Managing hypertension offers opportunities to delay type-2 diabetes onset.

Purpose:

  • To evaluate the impact of different antihypertensive drug classes on type-2 diabetes incidence.
  • To compare the efficacy of renin-angiotensin blockers versus other therapies in preventing diabetes.

Summary:

  • Renin-angiotensin blockers (ACE-inhibitors and Angiotensin II antagonists) show a 22% lower incidence of diabetes compared to other treatments.
  • Beta-blocker and diuretic combinations are associated with a higher risk of developing type-2 diabetes.
  • The ALLHAT trial indicated the lowest diabetes incidence with ACE-inhibitors and the highest with thiazide diuretics.

Impact:

  • Findings suggest a potential role for specific antihypertensive agents in diabetes prevention strategies.
  • Further research, including NAVIGATOR and ONTARGET trials, is expected to confirm these results and elucidate mechanisms like insulin resistance reduction.

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