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Population-based platelet reference values for an Iranian population
P Adibi1, E Faghih Imani, M Talaei
1Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. adibi@med.mui.ac.ir
Insights
This study establishes crucial platelet count reference ranges for young adult Iranians, essential for accurate medical diagnosis and research. Findings reveal differences compared to Caucasian and African populations.
Area of Science:
- Hematology
- Clinical Pathology
Background:
- Limited data exists on platelet indices reference ranges in Iran and surrounding regions, with prior studies having small sample sizes.
- Establishing population-specific reference values is vital for accurate medical research and clinical practice.
Purpose of the Study:
- To determine the reference values for platelet indices in a large cohort of young adult Iranians.
- To provide essential data for medical research and clinical practice in the region.
Main Methods:
- A cross-sectional survey was conducted on 19,993 young adult Iranians undergoing pre-marriage screening.
- Platelet indices including platelet count, platelet distribution width, plateletcrit, and mean platelet volume were measured using an automated hematology analyzer (Technicon H2).
Main Results:
- The study established 95% reference intervals for platelet indices in Iranians: platelet count (145-356 x 10^9/l), platelet distribution width (40.2-57.4%), plateletcrit (0.13-0.32%), and mean platelet volume (7.4-10.7 fl).
- Significant sex-based differences were observed for the first three indices (platelet count, PDW, and plateletcrit).
- Iranian reference values for platelet indices were found to be lower than Caucasians but higher than Africans.
Conclusions:
- The established reference values for platelet indices in young adult Iranians differ from international data.
- These findings underscore the importance of using population-specific reference ranges for accurate interpretation of platelet indices in clinical settings and research.
Abstract:
There are a few reports regarding the reference range for platelet indices in the populations of Iran and its neighbouring countries, but these studies were of small sample size. This study aimed at defining platelet reference values for medical research and practice. A cross-sectional survey was performed on 19,993 young adult Iranians who participated in a compulsory pre-marriage screening programme over a 6-month period. Platelet indices were measured using an automated Technicon H2 cell counter. The platelet count [given as 95% reference interval (2.5 percentile-97.5 percentile) and mean +/- standard deviation] were 145-356 x 10(9)/l (237 +/- 55.2); the platelet distribution width was 40.2-57.4% (46.9 +/- 5.7) the Plateletocrit was, 0.13-0.32% (0.22 +/- 0.05) and the mean platelet volume was 7.4-10.7 fl (9.2 +/- 2.9). The first three indices showed significant differences between males and females. The reference values of platelet indices in Iranians were found to be different from international data; they were a little lower than those in Caucasians but higher than the indices found for Africans.
