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Genomics and proteomics in process development: opportunities and challenges.

Prateek Gupta1, Kelvin H Lee

  • 1School of Chemical and Biomolecular Engineering, Cornell University, 120 Olin Hall, Ithaca, NY 14853, USA.

Trends in Biotechnology
|May 4, 2007
PubMed
Summary
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Genomic and proteomic analyses enhance recombinant protein production in mammalian cell cultures. These technologies offer valuable insights for bioprocess development, despite current limitations in genome sequencing data.

Area of Science:

  • Biotechnology
  • Molecular Biology
  • Bioprocess Engineering

Background:

  • Genomic and proteomic analyses have revolutionized drug discovery and biological research.
  • Their application in recombinant protein production, particularly in mammalian cell culture, is increasingly recognized.

Purpose of the Study:

  • To review the application of genome-wide expression profiling tools in bioprocess design and optimization.
  • To highlight the impact on mammalian cell culture process development.

Main Methods:

  • Utilizing genome-wide expression profiling (genomics and proteomics).
  • Applying these technologies across various bioprocess development stages.
  • Addressing challenges related to limited genome sequence information in mammalian cell lines.

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Main Results:

  • Few documented cases show major productivity improvements from genomics and proteomics.
  • Expression profiling aids in understanding molecular-level processes during bioprocessing.

Conclusions:

  • Genome-wide expression profiling tools are valuable for bioprocess development in mammalian cell culture.
  • Advancements in analytical and sequencing technologies will further enhance molecular understanding and future bioprocess design.