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Laparoscopic partial adrenalectomy for bilateral cortisol-secreting adenomas
Jeffrey P Domino1, Siok Bee Chionh, Davide Lomanto
1Endocrine Surgery Service, Department of Surgery, National University Hospital, Singapore.
Asian Journal of Surgery
|May 4, 2007
Summary
Bilateral cortisol-secreting adenomas, a rare cause of Cushing's syndrome, were successfully treated with laparoscopic adrenalectomy. This case highlights the feasibility of partial adrenalectomy for managing hypercortisolism, though long-term steroid independence requires further monitoring.
Area of Science:
- Endocrinology
- Surgical Oncology
Background:
- Cushing's syndrome can arise from rare bilateral cortisol-secreting adrenal adenomas.
- ACTH-independent Cushing's syndrome necessitates careful diagnostic evaluation.
Observation:
- A 35-year-old woman presented with ACTH-independent Cushing's syndrome and bilateral adrenal adenomas.
- Adrenal venous sampling confirmed bilateral cortisol hypersecretion.
Findings:
- The patient underwent successful bilateral laparoscopic adrenalectomy (total right, partial left).
- At 2-year follow-up, the patient is on low-dose steroid replacement and shows no hypercortisolism recurrence.
Implications:
- Laparoscopic partial adrenalectomy is a viable surgical option for bilateral cortisol-secreting adenomas.
- Long-term monitoring is essential to assess complete steroid independence post-surgery.
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