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Acute pancreatitis associated with ifosfamide

Miao-Chiu Hung1, Giun-Yi Hung, Pei-Chin Lin

  • 1Department of Pediatrics, Taipei Veterans General Hospital, and National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.

Journal of the Chinese Medical Association : JCMA
|May 4, 2007
PubMed

Insights

Acute pancreatitis is a rare chemotherapy complication. This case highlights late-onset pancreatitis in a child treated with ifosfamide (IFOS), a chemotherapy drug, after osteosarcoma treatment.

Area of Science:

  • Oncology
  • Pediatric Oncology
  • Gastroenterology

Background:

  • Acute pancreatitis is an uncommon but serious adverse event during chemotherapy for pediatric solid tumors.
  • Ifosfamide (IFOS) is an alkylating agent used in treating various pediatric cancers, including osteosarcoma.

Observation:

  • A 9-year-old boy diagnosed with osteosarcoma developed two distinct episodes of acute pancreatitis.
  • The first episode occurred one day post-ifosfamide infusion, and the second episode manifested 48 days after treatment.

Findings:

  • This report represents the third documented case of ifosfamide-induced pancreatitis and the second pediatric case.
  • Notably, this is the first reported instance of late-onset pancreatitis associated with ifosfamide treatment.

Implications:

  • The findings suggest a potential for delayed pancreatic toxicity from ifosfamide in pediatric oncology patients.
  • Clinicians should maintain a high index of suspicion for pancreatitis, including late-onset presentations, in children receiving ifosfamide.
  • Further investigation into the mechanisms and risk factors for ifosfamide-induced pancreatitis is warranted.

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