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Updated: Jul 15, 2026

In Vitro Differentiation of Human CD4+FOXP3+ Induced Regulatory T Cells (iTregs) from Naïve CD4+ T Cells Using a TGF-β-containing Protocol
08:20

In Vitro Differentiation of Human CD4+FOXP3+ Induced Regulatory T Cells (iTregs) from Naïve CD4+ T Cells Using a TGF-β-containing Protocol

Published on: December 30, 2016

TGF-beta1 modulates Foxp3 expression and regulatory activity in distinct CD4+ T cell subsets

M Pyzik1, C A Piccirillo

  • 1Department of Microbiology and Immunology and Strategic Training Centre in Infectious Diseases and Autoimmunity, McGill University, Montreal, Quebec, Canada.

Journal of Leukocyte Biology
|May 4, 2007
PubMed
Summary

Transforming T cells into regulatory cells depends on transforming growth factor-beta 1 (TGF-β1). This cytokine induces forkhead box p3 (Foxp3) expression in CD4(+)CD25(-)CD45RB(LOW) T cells, promoting IL-10-dependent regulatory functions.

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