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Related Experiment Video

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Model Surgical Training: Skills Acquisition in Fetoscopic Laser Photocoagulation of Monochorionic Diamniotic Twin Placenta Using Realistic Simulators
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Twin birth weight standards.

Marij Gielen1, Patrick J Lindsey, Catherine Derom

  • 1Nutrition and Toxicology Research Institute Maastricht (NUTRIM), Department of Population Genetics, Genomics and Bioinformatics, Maastricht University, Maastricht, The Netherlands. marij.gielen@gen.unimaas.nl

Neonatology
|May 4, 2007
PubMed
Summary

Customized birth weight standards for twins were developed, considering factors like gestational age and placental development. These standards improve the assessment of twin neonatal health and prenatal influences.

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Area of Science:

  • Perinatal Medicine
  • Reproductive Epidemiology
  • Maternal-Fetal Medicine

Background:

  • Accurate assessment of twin birth weight is crucial for neonatal health.
  • Existing birth weight standards may not adequately account for the complexities of twin pregnancies.
  • Understanding factors influencing twin birth weight is essential for optimizing outcomes.

Purpose of the Study:

  • To develop customized birth weight standards specifically for twins.
  • To evaluate the relative contributions of gestational age, maternal, twin, and placental factors to twin birth weight.
  • To provide a tool for better assessment of neonatal health in twins.

Main Methods:

  • Analysis of perinatal data from 10,177 live-born twins (8,454 with complete data) from the East Flanders Prospective Twin Survey.
  • Application of non-linear multivariate Gaussian regression to analyze birth weights across different gestational ages.
  • Multivariate approach to assess the influence of various covariates on twin birth weight.

Main Results:

  • Gestational age, maternal, twin, and placental factors significantly influenced twin birth weight, except for co-twin sex, conception, and delivery mode.
  • A difference of over 1 kg in birth weight was observed at 37 weeks based on prenatal environment.
  • Factors like sex, umbilical cord site, parity, and birth order had a greater impact than zygosity, chorionicity, or placental fusion up to 40 weeks.
  • The birth weight of the second-born twin deviated from 34 weeks; monozygotic monochorionic twins' birth weight decreased after 40 weeks.

Conclusions:

  • Customized twin-specific birth weight standards enhance the assessment of twin neonatal health.
  • These standards facilitate a better understanding of the impact of prenatal conditions on twin development.
  • The findings support the Developmental Origins of Health and Disease hypothesis in twin pregnancies.