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Remifentanil compared with midazolam and pethidine sedation during colonoscopy: a prospective, randomized study
Maria M Manolaraki1, Angeliki Theodoropoulou, Charalampos Stroumpos
1Department of Anesthesiology, Benizelion General Hospital, Heraklion-Crete, Greece.
Digestive Diseases and Sciences
|May 4, 2007
Summary
Remifentanil offers superior pain relief and faster recovery during colonoscopy compared to midazolam and pethidine. This study highlights remifentanil
Area of Science:
- Gastroenterology
- Anesthesiology
- Clinical Pharmacology
Background:
- Moderate sedation is commonly used for colonoscopy.
- Midazolam and pethidine are standard agents for colonoscopy sedation.
- Alternative agents are being investigated for improved patient outcomes.
Purpose of the Study:
- To compare the safety and efficacy of remifentanil versus midazolam and pethidine for colonoscopy.
- To evaluate recovery times and hospital discharge durations.
- To assess cardiorespiratory effects of different sedation methods.
Main Methods:
- 116 patients undergoing colonoscopy were randomized into two groups.
- Group A received intravenous midazolam and pethidine.
- Group B received intravenous remifentanil.
Main Results:
- Remifentanil group (B) showed significantly faster recovery (0 min) vs. midazolam/pethidine group (A) (56 min).
- Hospital discharge was quicker in group B (28.7 min) compared to group A (148.9 min).
- Midazolam/pethidine combination had a greater impact on cardiorespiratory parameters.
Conclusions:
- Remifentanil provides effective pain relief and better hemodynamic stability during colonoscopy.
- Remifentanil leads to significantly faster recovery and hospital discharge.
- Remifentanil is a favorable alternative to midazolam and pethidine for colonoscopy sedation.
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