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Related Experiment Videos

Subtrigonal phenol injection. How safe and effective is it?

C R Chapple1, S J Hampson, R T Turner-Warwick

  • 1Department of Urology, Middlesex Hospital, London.

British Journal of Urology
|November 1, 1991
PubMed
Summary
This summary is machine-generated.

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Transtrigonal phenol injections for bladder instability showed limited long-term effectiveness and potential for serious complications. This treatment is not recommended except for refractory detrusor hyperreflexia, with caution in complex cases.

Area of Science:

  • Urology
  • Neurosurgery
  • Pharmacology

Background:

  • Bladder instability and detrusor hyperreflexia are challenging conditions impacting quality of life.
  • Transtrigonal phenol injection has been explored as a minimally invasive treatment option.
  • Assessing the long-term efficacy and safety of this procedure is crucial.

Observation:

  • A series of 24 patients received 27 transtrigonal phenol injections for bladder instability.
  • Follow-up at 6 months revealed limited sustained benefit: only 2/18 with detrusor instability and 2/6 with detrusor hyperreflexia remained improved.
  • Serious complications related to phenol occurred in 2 patients, with 4 additional referred cases.

Findings:

  • Transtrigonal phenol injection demonstrates poor durability for bladder instability, with significant failure rates at 6 months.

Related Experiment Videos

  • The procedure carries a risk of serious complications, including those observed in this series and referred cases.
  • Efficacy is notably low in patients with detrusor instability compared to detrusor hyperreflexia.

    • Implications:

    • Transvesical phenol injection should be reserved for hyper-reflexic bladders unresponsive to other treatments.
    • Extreme caution is advised for patients with a history of extensive surgery or radiotherapy due to heightened risk.
    • Further research into safer and more effective treatments for bladder instability is warranted.