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Updated: Jul 15, 2026

Minimizing Post-Infusion Portal Vein Bleeding during Intrahepatic Islet Transplantation in Mice
Published on: May 10, 2021
Cotransplanted hepatic stellate cells enhance vascularization of islet allografts
Zhenyu Yin1, Wenhan Wu, John J Fung
1Department of Immunology, Cleveland Clinic, Cleveland, OH 44195, USA.
Abstract:
Islet transplantation is an alternative to whole pancreas transplantation in curative therapy of diabetics. The outcome of engraftment of islet, however, remains disappointing. Rapid and adequate islet revascularization is crucial for the survival and function of transplanted islets. In this study, hepatic stellate cells (HSC) were cotransplanted with islet allografts, achieving marked prolongation of islet allografts. This was associated with enhanced revascularization within islet grafts as determined by anti-CD31 antibody staining.
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