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[Pediatric heart transplantation 1990].

C Chartrand1

  • 1Département de chirurgie cardio-vasculaire, Hôpital Sainte-Justine, Montréal, Qué.

Canadian Journal of Surgery. Journal Canadien De Chirurgie
|December 1, 1991
PubMed
Summary

Pediatric cardiac transplantation is viable for children with birth defects, showing a 78% two-year survival rate. Innovative surgical techniques and immunosuppression management improve outcomes in pediatric heart recipients.

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Risk factors for acute rejection after pediatric heart transplantation.

Transplantation proceedings·2001

Area of Science:

  • Cardiology
  • Pediatric Surgery
  • Immunology

Context:

  • Pediatric cardiac transplantation is a complex procedure with evolving outcomes.
  • Congenital heart defects historically posed challenges for transplantation candidacy.
  • Ste-Justine Hospital (SJH) has reviewed its experience and relevant literature.

Purpose:

  • To evaluate the feasibility and outcomes of pediatric cardiac transplantation.
  • To assess the impact of birth defects on transplant success.
  • To analyze immunosuppression strategies and patient survival.

Summary:

  • Fifteen children (aged 3-16) underwent cardiac transplantation, with 10 having repaired birth defects.
  • Survival at two years was 78% with triple-drug immunosuppression (cyclosporine 100-200 ng/mL).
  • Acute rejection (0.5 episodes/patient) and renal function were managed effectively; hypertension was reversible.

Impact:

  • Demonstrates that birth defects are not contraindications for pediatric cardiac transplantation.
  • Highlights successful management of immunosuppression, leading to preserved renal function and good cardiac activity.
  • Provides evidence for improved surgical techniques and graft management in pediatric heart transplantation.

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