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Translocation (Y;2) in childhood acute lymphoblastic leukemia
J R Kowalczyk1, M Chobotow, G Sladkowska
1Institute of Pediatrics, Lublin, Poland.
Cancer Genetics and Cytogenetics
|October 1, 1991
Abstract:
A case of ALL in a 2 1/2-year-old boy with fatal outcome is presented. Cytogenetic analysis revealed a hypodiploid karyotype: 45,X-Y,-2,+der (2)t(Y;2),-12,i(17q),+mar. Some metaphases represented a sideline with 44 chromosomes and monosomy 8 was a consistent anomaly. These findings are rather uncommon in ALL. Hypodiploidy and the translocation, however, indicated poor prognosis in this case.