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Updated: Jul 15, 2026

Efficient Isolation Protocol for B and T Lymphocytes from Human Palatine Tonsils
Published on: November 16, 2015
Lymphoid polyps of the palatine tonsil
Icleia Barreto1, Priscila Juliano, Cristiano Chagas
1Department of Pathology, School of Medicine, University of Campinas, Campinas, Brazil.
Tonsillar lymphoid polyps are rare growths, possibly hamartomas, characterized by lymphoid tissue overgrowth. These polyps maintain the normal cellular composition and architecture of palatine tonsil lymphoid tissue.
Area of Science:
- Pathology
- Otolaryngology
- Immunohistochemistry
Background:
- Tonsillar lymphoid polyps are uncommon lesions with limited research.
- Understanding their nature is crucial for accurate diagnosis and management.
Purpose of the Study:
- To investigate the clinical, histopathologic, and immunohistochemical features of tonsillar lymphoid polyps.
- To determine the cellular composition and architectural patterns of these lesions.
Main Methods:
- Clinical data collection for presenting symptoms.
- Histopathologic examination of polyp tissue.
- Immunohistochemical analysis using markers for B cells, T cells, plasma cells, and vessels.
Main Results:
- Six cases of tonsillar lymphoid polyps were analyzed, with lymphoid tissue comprising over 80% of the lesions.
- Microscopically, polyps showed follicles with germinal centers and lymphoepithelium-lined crypts.
- Immunohistochemistry confirmed normal distribution and architectural patterns of B cells, T cells, plasma cells, and vessels.
Conclusions:
- Tonsillar lymphoid polyps are likely hamartomas resulting from lymphoid element overgrowth.
- These polyps exhibit a cellular composition and architecture similar to normal palatine tonsil lymphoid tissue.
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