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Updated: Jul 15, 2026

Determination of the Transport Rate of Xenobiotics and Nanomaterials Across the Placenta using the ex vivo Human Placental Perfusion Model
08:08

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Concentrations of methadone in breast milk and plasma in the immediate perinatal period

Lauren M Jansson1, Robin E Choo, Cheryl Harrow

  • 1Center for Addiction and Pregnancy, Johns Hopkins Bayview Medical Center, Baltimore, MD 21224, USA. ljansson@jhmi.edu

Journal of Human Lactation : Official Journal of International Lactation Consultant Association
|May 5, 2007
PubMed

This study evaluates concentrations of methadone in breast milk and plasma among a sample of methadone-maintained women in the immediate perinatal period. Twelve methadone-maintained, lactating women provided blood and breast milk specimens 1, 2, 3, and 4 days after delivery. Specimens were collected at the time of trough (just before methadone dose) and peak (3 hours after dosing) maternal methadone levels. Paired specimens of foremilk (prefeed) and hindmilk (postfeed) were obtained at each sampling time. Although there was a significant increase in methadone concentration in breast milk over time for the peak postfeed sampling time, t (22)=2.40, P=.0255, methadone concentrations in breast milk were small, ranging from 21 to 314 ng/mL, and were unrelated to maternal methadone dose. Results obtained from this study contribute to the recommendation of breastfeeding for methadone-maintained women regardless of methadone dose.

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