Related Experiment Video
Updated: Jul 15, 2026
06:44
Deep Vein Thrombosis Induced by Stasis in Mice Monitored by High Frequency Ultrasonography
Published on: April 13, 2018
Local heparin, superficial vein thrombosis
Maria Rosaria Cesarone1, Gianni Belcaro, M Corsi
1Vascular Lab, Department of Biomedical Science, G D'Annunzio University, Pescara; San Valentino Vascular Screening Project, Italy.
Angiology
|May 5, 2007
Summary
Local heparin offers promising therapeutic effects on the skin, including anticoagulant and microcirculatory modulation. New formulations may enhance drug delivery and treat superficial vein thrombosis effectively.
Area of Science:
- Dermatology and Pharmacology
- Vascular Medicine
Background:
- Local, topical effects of heparins on skin require further investigation due to limited research.
- Heparin exhibits three primary local actions on the skin: anticoagulant, microcirculatory modulation, and enhanced skin permeability for drug delivery.
Purpose of the Study:
- To explore the potential clinical applications of locally administered heparin, particularly novel formulations.
- To evaluate the efficacy of topical heparin in managing superficial vein thrombosis.
Main Methods:
- Review of recent experimental studies on locally applied heparin.
- Analysis of clinical observations and new study results concerning topical heparin administration.
Main Results:
- Experimental studies support the local anticoagulant and microcirculatory effects of heparin on the skin.
- Local heparin demonstrates potential for enhancing skin permeability, facilitating drug diffusion.
- Topical heparin shows promise in addressing superficial vein thrombosis.
Conclusions:
- Local heparin, especially in advanced formulations like liposomal heparin, has significant potential for various dermatological and vascular applications.
- Further research and clinical evaluation are warranted to fully establish the therapeutic benefits of topical heparin, particularly for superficial vein thrombosis.
Related Concept Videos
01:20Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies
The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
01:30Venous Thrombosis I: Introduction
Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
01:29Venous Thrombosis III: Interprofessional Care
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
01:30Anticoagulant Drugs: Low-Molecular-Weight Heparins
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
01:15Veins of Lower Limbs
The human body consists of an intricate network of veins responsible for the crucial task of blood drainage from the lower limbs. These veins can be categorized into two main types: deep veins and superficial veins.
Formed by the union of the medial and lateral plantar veins, the posterior tibial vein, rising through the calf muscle, assimilates the fibular vein. The anterior tibial vein, a superior extension of the foot's dorsalis pedis vein, merges with the posterior tibial vein at the knee,...
Formed by the union of the medial and lateral plantar veins, the posterior tibial vein, rising through the calf muscle, assimilates the fibular vein. The anterior tibial vein, a superior extension of the foot's dorsalis pedis vein, merges with the posterior tibial vein at the knee,...
01:30Venous Thrombosis IV: Nursing Management
Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...