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The specific role of chemokines in atherosclerosis

Vincent Braunersreuther1, François Mach, Sabine Steffens

  • 1Division of Cardiology, Department of Medicine, Geneva University Hospital, Foundation for Medical Researches, 64 Avenue Roseraie, 1211 Geneva, Switzerland.

Thrombosis and Haemostasis
|May 5, 2007
PubMed

Insights

Blocking chemokine and chemokine receptor interactions may treat atherosclerosis and related heart conditions. Targeting leukocyte recruitment offers potential therapeutic strategies for inflammatory diseases like myocardial infarction.

Area of Science:

  • Cardiovascular Science
  • Immunology
  • Inflammation Biology

Background:

  • Atherosclerosis is a chronic inflammatory condition causing heart disease and stroke.
  • Inflammatory cell recruitment to the intima is crucial for atherosclerosis development.
  • Chemokines and their receptors mediate this inflammatory cell recruitment.

Purpose of the Study:

  • To explore the role of chemokines in atherosclerosis.
  • To investigate the potential of targeting chemokine pathways for therapeutic intervention.

Main Methods:

  • Review of existing literature on chemokine involvement in atherosclerosis.
  • Analysis of findings from animal models investigating chemokine antagonists.

Main Results:

  • Several CC and CXC chemokine families, including MCP-1/CCL2, IL-8/CCL8, IP-10/CXCL10, SDF-1/CXCL12, and fractalkine/CX3CL1, are implicated in atherosclerosis.
  • Animal models suggest blocking chemokine/chemokine receptor interactions can impede atherosclerosis progression.

Conclusions:

  • Chemokine pathways are critical in the inflammatory processes underlying atherosclerosis.
  • Inhibiting chemokine-mediated leukocyte recruitment presents a promising therapeutic avenue for atherosclerosis and myocardial infarction treatment.

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