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Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
Published on: June 23, 2019
New pyrazolic compounds as cytotoxic agents
Ibrahim Bouabdallah1, Lahcen Ait M'Barek, Abdelmajid Zyad
1Laboratory of Organic Chemistry, Macromolecular and Natural Products, Faculty of Sciences, University Mohammed Ier, 60 000 Oujda, Morocco.
Abstract:
The evaluation of the in vitro cytotoxic properties of two pyrazole compounds: 1-(4-nitrophényl)-3,5-diméthylpyrazole (1) and 1,1'-di(4-nitrophényl)-5,5'-diisopropyl-3,3'-bipyrazole (2) was investigated against Hep cell line (Human laryngeal carcinoma). These two compounds showed an important cytotoxic activity on the Hep cell line, with IC(50): 8.25 microg mL(-1) for the compound 1; IC(50): 10.20 microg mL(-1) for the compound 2 while the IC(50) for adriamycine used as positive control was 3.62 microg mL(-1).
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