New pyrazolic compounds as cytotoxic agents
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Updated: Jul 15, 2026

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
Published on: June 23, 2019
Ibrahim Bouabdallah1, Lahcen Ait M'Barek, Abdelmajid Zyad
1Laboratory of Organic Chemistry, Macromolecular and Natural Products, Faculty of Sciences, University Mohammed Ier, 60 000 Oujda, Morocco.
Abstract:
The evaluation of the in vitro cytotoxic properties of two pyrazole compounds: 1-(4-nitrophényl)-3,5-diméthylpyrazole (1) and 1,1'-di(4-nitrophényl)-5,5'-diisopropyl-3,3'-bipyrazole (2) was investigated against Hep cell line (Human laryngeal carcinoma). These two compounds showed an important cytotoxic activity on the Hep cell line, with IC(50): 8.25 microg mL(-1) for the compound 1; IC(50): 10.20 microg mL(-1) for the compound 2 while the IC(50) for adriamycine used as positive control was 3.62 microg mL(-1).
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