Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Blood-brain Barrier00:49

The Blood-brain Barrier

52.4K
Overview
52.4K
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

4.0K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
4.0K
Receptor Downregulation in MVBs01:15

Receptor Downregulation in MVBs

2.8K
Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
The EGFR can initiate signaling pathways that  lead to cell proliferation, migration, and differentiation. Overexpression of EGFR  stimulates cells to proliferate. Excessive  EGFR...
2.8K
Negative Regulator Molecules01:23

Negative Regulator Molecules

38.3K
Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
38.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pair bonding sex-specifically improves object recognition memory in monogamous prairie vole.

Physiology & behavior·2026
Same author

Generating Biologically Relevant Subtypes of Autism Spectrum Disorder with differential responses to Acute Oxytocin Administration in a Randomized Trial using Random Forest Models and K-means Clustering.

medRxiv : the preprint server for health sciences·2026
Same author

Stress History Modulates Corticotropin-Releasing Factor Neurons to Establish Resilience.

Biological psychiatry global open science·2026
Same author

Natural variation in the oxytocin receptor gene predicts social observation in female prairie voles.

bioRxiv : the preprint server for biology·2025
Same author

CRISPR-mediated knockdown of oxytocin receptor in extended amygdala reduces stress-induced social avoidance in female California mice.

Hormones and behavior·2025
Same author

CRISPR-mediated knockdown of oxytocin receptor in extended amygdala reduces stress-induced social avoidance in female California mice.

bioRxiv : the preprint server for biology·2025

Related Experiment Video

Updated: Jan 17, 2026

Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies
09:08

Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies

Published on: June 2, 2021

2.1K

Regulating the social brain: a new role for CD38.

Larry J Young1

  • 1Department of Psychiatry and Behavioral Sciences, Center for Behavioral Neuroscience, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30322, USA. lyoun03@emory.edu

Neuron
|May 8, 2007
PubMed
Summary

The transmembrane receptor CD38 regulates social behaviors by controlling oxytocin (OT) release from hypothalamic neurons. This finding highlights CD38's critical role in social functions.

More Related Videos

Continuous Theta Burst Stimulation of the Posterior Medial Frontal Cortex to Experimentally Reduce Ideological Threat Responses
06:42

Continuous Theta Burst Stimulation of the Posterior Medial Frontal Cortex to Experimentally Reduce Ideological Threat Responses

Published on: September 28, 2018

12.1K
Murine Model of CD40-activation of B cells
12:24

Murine Model of CD40-activation of B cells

Published on: March 5, 2010

13.2K

Related Experiment Videos

Last Updated: Jan 17, 2026

Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies
09:08

Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies

Published on: June 2, 2021

2.1K
Continuous Theta Burst Stimulation of the Posterior Medial Frontal Cortex to Experimentally Reduce Ideological Threat Responses
06:42

Continuous Theta Burst Stimulation of the Posterior Medial Frontal Cortex to Experimentally Reduce Ideological Threat Responses

Published on: September 28, 2018

12.1K
Murine Model of CD40-activation of B cells
12:24

Murine Model of CD40-activation of B cells

Published on: March 5, 2010

13.2K

Area of Science:

  • Neuroscience
  • Endocrinology
  • Molecular Biology

Background:

  • Oxytocin (OT) is a key neurohormone centrally regulating social behaviors, including maternal care, social memory, and bonding.
  • The precise molecular mechanisms governing OT release from hypothalamic neurons remain an active area of research.

Purpose of the Study:

  • To investigate the role of the transmembrane receptor CD38 in the regulation of oxytocin release and social behaviors.

Main Methods:

  • Utilized genetic and pharmacological approaches to manipulate CD38 expression and activity in relevant neuronal populations.
  • Measured oxytocin levels and assessed social behaviors in experimental models.

Main Results:

  • Demonstrated that CD38 is critically involved in regulating the release of oxytocin from hypothalamic neurons.
  • Showcased the significant impact of CD38 on modulating social behaviors.

Conclusions:

  • The transmembrane receptor CD38 is a key regulator of oxytocin release.
  • CD38 represents a novel molecular target for understanding and potentially influencing social behaviors.