Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Timing is everything: making neurons versus glia in the developing cortex.

Freda D Miller1, Andrée S Gauthier

  • 1Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto M5G 1X8, Canada. fredam@sickkids.ca

Neuron
|May 8, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Single-cell multiomic approaches define a gradual, spatially regulated epigenetic and transcriptional transition from embryonic to adult neural stem cells.

Stem cell reports·2026
Same author

Author Correction: p75NTR-dependent, myelin-mediated axonal degeneration regulates neural connectivity in the adult brain.

Nature neuroscience·2025
Same author

Single-Cell Approaches Define the Murine Leptomeninges: Cortical Brain Interface as a Distinct Cellular Neighborhood Composed of Neural and Non-neural Cell Types.

eNeuro·2025
Same author

A 3D human iPSC-derived multi-cell type neurosphere system to model cellular responses to chronic amyloidosis.

Journal of neuroinflammation·2025
Same author

Neural stem cell quiescence and activation dynamics are regulated by feedback input from their progeny under homeostatic and regenerative conditions.

Cell stem cell·2025
Same author

Single cell approaches define neural stem cell niches and identify microglial ligands that can enhance precursor-mediated oligodendrogenesis.

Cell reports·2025
Same journal

Fast-conducting mechanonociceptors uniquely engage reflexive and affective pain circuitry to drive protective responses.

Neuron·2026
Same journal

Sparse component analysis: A method that uncovers separable computations within neural population activity.

Neuron·2026
Same journal

Spatiomolecular mapping reveals anatomical organization of heterogeneous cell types in the human nucleus accumbens.

Neuron·2026
Same journal

TGF-β1-induced endothelial transcytosis drives blood-brain barrier leakage during aging.

Neuron·2026
Same journal

Image space opens up for visual neuroscience.

Neuron·2026
Same journal

Septal GLP-1 receptors control alcohol taking and seeking.

Neuron·2026
See all related articles

Mammalian nervous system development involves neural stem cells creating neurons before glia. This review explores the epigenetic, transcriptional, and environmental factors controlling this crucial timing for neural circuitry formation.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Cell Biology

Background:

  • Mammalian nervous system development follows a specific temporal sequence, with neural stem cells generating neurons prior to glial cells.
  • This precise timing is essential for establishing functional neural circuitry and ensuring appropriate glial support.
  • Understanding the mechanisms governing this temporal cell fate determination is critical in developmental neuroscience.

Purpose of the Study:

  • To review the mechanisms underlying the timed generation of neurons and glia from neural stem cells.
  • To focus on the specific processes occurring during the development of the mammalian cortex.
  • To elucidate the interplay of factors controlling this biological timing.

Main Methods:

  • Literature review of studies on mammalian nervous system development.

Related Experiment Videos

  • Analysis of research focusing on the developing cerebral cortex.
  • Synthesis of findings on intrinsic and extrinsic regulatory mechanisms.

    • Main Results:

    • Neural stem cells exhibit a developmental timeline producing neurons first, then glia.
    • This temporal control is orchestrated by a complex interplay of factors.
    • Key elements include intrinsic epigenetic status, specific transcription factors, and external environmental cues.

    Conclusions:

    • The sequential generation of neurons and glia is a tightly regulated process.
    • Epigenetic modifications, transcription factors, and environmental signals collectively govern this timing.
    • This mechanism ensures the proper formation and functional maturation of neural circuits.