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Related Experiment Videos

Homophilic Dscam interactions control complex dendrite morphogenesis.

Michael E Hughes1, Rachel Bortnick, Asako Tsubouchi

  • 1Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

Neuron
|May 8, 2007
PubMed
Summary
This summary is machine-generated.

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Drosophila Dscam protein isoforms regulate neuronal wiring by preventing dendrite self-crossing. This isoform-specific homophilic binding ensures neuronal self-avoidance, not tiling between different neurons.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • Alternative splicing of the Drosophila gene Dscam generates numerous receptor isoforms.
  • These isoforms are proposed to mediate interactions via isoform-specific homophilic binding.

Purpose of the Study:

  • To investigate the role of Dscam in neuronal wiring and dendrite guidance.
  • To determine if Dscam mediates self-avoidance and/or heteroneuronal tiling.

Main Methods:

  • Studied Dscam function in Drosophila dendrite arborization (da) neurons.
  • Utilized genetic mutations to observe loss-of-function effects.
  • Employed overexpression experiments to assess functional interactions.

Main Results:

Related Experiment Videos

  • Dscam controls cell-intrinsic dendrite guidance, with loss causing increased self-crossing.
  • Dendritic self-avoidance, but not heteroneuronal tiling, appears dependent on Dscam.
  • Overexpression of identical Dscam isoforms in adjacent neurons induced spatial segregation.

    • Conclusions:

    • Dscam's isoform-specific homophilic binding mediates dendritic self-avoidance.
    • This mechanism allows for cell-intrinsic repulsion without affecting heteroneuronal interactions.