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Updated: Jul 12, 2026

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
Published on: November 16, 2013
Cytochrome P450 gene regulation and physiological functions mediated by the aryl hydrocarbon receptor
Kaname Kawajiri1, Yoshiaki Fujii-Kuriyama
1Research Institute for Clinical Oncology, Saitama Cancer Center, Ina-machi 818, Kitaadachi-gun, Saitama 362-0806, Japan.
Abstract:
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that functions as an intracellular mediator in the xenobiotic signaling pathway. Although a number of studies have examined AhR-mediated CYP1A1 induction in detail, recent studies of AhR-null mice have revealed that AhR plays important regulatory roles in the normal homeostasis and development of animals. In this short review, we summarize the present state of knowledge about the molecular mechanisms of AhR-mediated CYP1 induction, and we also focus on recent advances in the study of the physiological functions of AhR.
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