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Isolation of Fidelity Variants of RNA Viruses and Characterization of Virus Mutation Frequency
18:10

Isolation of Fidelity Variants of RNA Viruses and Characterization of Virus Mutation Frequency

Published on: June 16, 2011

Insights into RNA virus mutant spectrum and lethal mutagenesis events: replicative interference and complementation

Celia Perales1, Roberto Mateo, Mauricio G Mateu

  • 1Centro de Biología Molecular, Severo Ochoa CSIC-UAM, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain.

Journal of Molecular Biology
|May 8, 2007
PubMed
Summary

Specific foot-and-mouth disease virus (FMDV) mutants interfere with wild-type RNA replication. This interference depends on mutant RNA levels and intracellular replication, supporting models of viral extinction through enhanced mutagenesis.

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