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Laparoscopic Repair of Para-Esophageal Hernia Using Absorbable Biosynthetic Mesh
Published on: September 11, 2021
Interposition of polyglactin mesh does not prevent adhesion formation between viscera and polypropylene mesh
Tammo S de Vries Reilingh1, Harry van Goor, Manuel J Koppe
1Department of Surgery, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. t.devriesreilingh@chir.umcn.nl
The Journal of Surgical Research
|May 8, 2007
Summary
Using a resorbable polyglactin 910 mesh (PGM) between polypropylene mesh (PPM) and viscera did not change adhesion or herniation rates in rats. This study found no benefit in preventing complications with this interposition technique.
Area of Science:
- Biomaterials Science
- Surgical Innovation
- Hernia Repair Research
Background:
- Intra-peritoneal polypropylene mesh (PPM) for incisional hernia repair risks adhesions and visceral damage.
- Polyglactin 910 mesh (PGM) is proposed to prevent direct contact between PPM and viscera.
Purpose of the Study:
- To evaluate if interposing a resorbable prosthesis (PGM) between PPM and viscera impacts biocompatibility, adhesion formation, and herniation rates.
- To assess the histological changes and clinical outcomes of PPM versus PPM-PGM repair in an animal model.
Main Methods:
- An abdominal wall defect was created in 80 rats, randomly assigned to PPM or PPM-PGM repair.
- Rats were sacrificed at 1, 2, 3, and 6 months for autopsy to assess herniation and adhesion rates.
- Mesh-fascia interface samples were collected for histological analysis.
Main Results:
- Herniation rates were comparable between the PPM and PPM-PGM groups at 6 months.
- Adhesion scores at 1, 2, 3, and 6 months showed no significant difference between the two groups.
- Histology revealed similar tissue responses, with a more evident early inflammatory response in the PPM-PGM group.
Conclusions:
- Interposition of PGM between PPM and viscera does not alter adhesion formation.
- The herniation rate is not influenced by the interposition of PGM.
- The study suggests no added benefit of PGM interposition for preventing adhesions or herniation in this model.
