Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Caspases and receptor cleavage.

Dirk Graf1, Johannes G Bode, Dieter Häussinger

  • 1Department of Gastroenterology, Hepatology and Infectiology, Heinrich-Heine University, Düsseldorf, Germany. DirkGraf@gmx.net

Archives of Biochemistry and Biophysics
|May 8, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Murine leukemia virus resists producer cell APOBEC3A by its Glycosylated Gag but not target cell APOBEC3A.

Virology·2021
Same author

Variation of vital signs with potential to influence the performance of qSOFA scoring in the Ethiopian general population at different altitudes of residency: A multisite cross-sectional study.

PloS one·2021
Same author

Efficiently Restored Thrombopoietin Production by Ashwell-Morell Receptor and IL-6R Induced Janus Kinase 2/Signal Transducer and Activator of Transcription Signaling Early After Partial Hepatectomy.

Hepatology (Baltimore, Md.)·2020
Same author

HIV-2 Vif and foamy virus Bet antagonize APOBEC3B by different mechanisms.

Virology·2020
Same author

Carriage of ESBL-producing Gram-negative bacteria by flies captured in a hospital and its suburban surroundings in Ethiopia.

Antimicrobial resistance and infection control·2020
Same author

Correction to: The role of passive immunization in the age of SARS-CoV-2: an update.

European journal of medical research·2020
Same journal

Cortical Cholesterol Deficit and Reduced Network Excitability in ApoE-Deficient Mice.

Archives of biochemistry and biophysics·2026
Same journal

Unraveling zinc's impact: Variable effects across concentrations in Phaseolus coccineus thylakoids.

Archives of biochemistry and biophysics·2026
Same journal

Characterizing tumor-associated endothelial cells in clear cell renal cell carcinoma via scRNA-seq and Bulk RNA-seq: construction of a prognostic risk signature.

Archives of biochemistry and biophysics·2026
Same journal

FOSB-Histone deacetylase 6 axis drives hepcidin-mediated ferroptosis in pulmonary ischemia-reperfusion injury.

Archives of biochemistry and biophysics·2026
Same journal

Sevoflurane preconditioning alleviates hypoxia-reoxygenation-induced myocardial injury via regulating the MIR210HG/miR-377-3p/PUM2 axis.

Archives of biochemistry and biophysics·2026
Same journal

Structural and kinetic analysis of human NQO1: Evidence for therapeutic inhibition by racemic warfarin.

Archives of biochemistry and biophysics·2026
See all related articles

Caspases, enzymes involved in cell death, also regulate cell survival by cleaving dependence receptors. This caspase activity releases fragments or exposes death domains, potentially halting survival signals and promoting cell toxicity.

Area of Science:

  • Cellular Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Caspases are primarily known for their role in programmed cell death (apoptosis).
  • Emerging evidence suggests caspases participate in diverse cellular processes beyond apoptosis.
  • Dependence receptors are a class of proteins regulating cell survival, homeostasis, and programmed cell death.

Purpose of the Study:

  • To explore the non-apoptotic functions of caspases.
  • To investigate the role of caspases in the regulation of dependence receptors and other plasma membrane receptors.
  • To elucidate the signaling mechanisms by which caspases influence cell survival and toxicity.

Main Methods:

  • Analysis of caspase activity on dependence receptors (e.g., RET, DCC) and other receptors (e.g., EGFR).

Related Experiment Videos

  • Investigation of caspase-mediated cleavage sites and their functional consequences.
  • Signal transduction pathway analysis following caspase-mediated receptor modification.

    • Main Results:

    • Caspase-mediated cleavage of dependence receptors releases pro-apoptotic fragments (e.g., RET) or unmasks death domains (e.g., DCC).
    • Caspase activity on plasma membrane receptors like EGFR blocks ligand-induced signaling.
    • This cleavage mechanism may represent a pathway for caspases to induce cell toxicity by inhibiting survival signals.

    Conclusions:

    • Caspases possess critical functions beyond apoptosis, including the regulation of cell survival pathways.
    • Cleavage of dependence receptors and other signaling receptors by caspases is a key mechanism influencing cellular fate.
    • Understanding these non-apoptotic roles of caspases provides insights into cellular homeostasis and toxicity.