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NK cells and pre-eclampsia.

I L Sargent1, A M Borzychowski, C W G Redman

  • 1Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK. ian.sargent@obs-gyn.ox.ac.uk

Journal of Reproductive Immunology
|May 8, 2007
PubMed
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Maternal immune interactions with the fetus may primarily involve natural killer (NK) cells, not T cells. Aberrant NK cell activity could be linked to pre-eclampsia development.

Area of Science:

  • Immunology
  • Reproductive immunology
  • Maternal-fetal interface immunology

Background:

  • Classical view: maternal T cells respond to paternal antigens.
  • Human trophoblast MHC antigen expression and decidual immune cells suggest a different interaction.
  • Pregnancy involves a maternal systemic immune response, the Th1/Th2 shift.

Purpose of the Study:

  • To investigate the primary immune cells involved in maternal-fetal interaction.
  • To explore the role of decidual natural killer (NK) cells in pregnancy immunology.
  • To examine the involvement of NK cells in the maternal systemic immune response during pregnancy.

Main Methods:

  • Analysis of MHC antigen expression on human trophoblast.
  • Characterization of immune cell populations in the decidua.

Related Experiment Videos

  • Functional studies on immune cell interactions.
  • Investigation of maternal systemic immune response (Th1/Th2 shift) involving NK cells.

    • Main Results:

    • Evidence suggests decidual NK cells, rather than T cells, are key in maternal-fetal immune interaction.
    • Functional studies support the predominant role of NK cells.
    • NK cells are implicated in the maternal systemic immune response (Th1/Th2 shift).

    Conclusions:

    • The maternal-fetal immunological dialogue is likely mediated primarily by decidual NK cells.
    • Aberrant NK cell activation, both locally and systemically, may contribute to pre-eclampsia pathogenesis.