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Published on: May 31, 2017
Approaches to neural tissue engineering using scaffolds for drug delivery
Stephanie M Willerth1, Shelly E Sakiyama-Elbert
1Department of Biomedical Engineering, Washington University in St Louis, St Louis, MO 63130, USA.
Advanced Drug Delivery Reviews
|May 8, 2007
Summary
This review explores drug delivery from scaffolds for neural tissue engineering. It covers scaffold materials, drugs, and delivery methods to advance brain, spinal cord, and peripheral nerve repair.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Neuroscience
Background:
- Neural tissue engineering faces challenges in replicating complex nervous system tissues.
- Effective drug delivery from scaffolds is crucial for successful neural regeneration.
Purpose of the Study:
- To provide a comprehensive overview of current drug delivery strategies from scaffolds for neural tissue engineering.
- To analyze scaffold materials, target drugs, and various drug delivery systems.
Main Methods:
- Review of existing literature on scaffold materials (synthetic and natural) and drugs.
- Examination and critique of drug delivery methods: diffusion-based, affinity-based, immobilized, and electrically controlled systems.
Main Results:
- Discussion of benefits and drawbacks of various scaffold materials and drug delivery techniques.
- Identification of challenges in replicating brain, spinal cord, and peripheral nerve environments.
Conclusions:
- Drug delivery from scaffolds is a key area for advancing neural tissue engineering.
- Future research should focus on optimizing delivery systems for specific neural repair applications.
