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In vivo multiecho T2 relaxation measurements using variable TR to decrease scan time.

Cornelia Laule1, Shannon Heather Kolind, Thorarin Albert Bjarnason

  • 1Department of Radiology, University of British Columbia Hospital, Vancouver BC, Canada V6T 2B5. claule@physics.ubc.ca

Magnetic Resonance Imaging
|May 8, 2007
PubMed
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This study introduces a faster multiecho T2 relaxation measurement technique. The variable TR method significantly reduces scan time for myelin water fraction (MWF) and geometric mean T2 (GMT2) imaging without compromising accuracy.

Area of Science:

  • Magnetic Resonance Imaging (MRI)
  • Neuroimaging
  • Biomedical Engineering

Background:

  • Standard multiecho T2 relaxation measurements for geometric mean T2 (GMT2) and myelin water fraction (MWF) are time-consuming.
  • Extended scan times lead to motion artifacts, reduced patient comfort, and decreased compliance.
  • Need for accelerated MRI techniques in quantitative myelin imaging.

Purpose of the Study:

  • To develop and validate a shortened acquisition protocol for multiecho T2 measurements.
  • To maintain T1-weighted contrast while reducing scan duration by varying the repetition time (TR) across k-space.
  • To assess the impact of the variable TR approach on quantitative T2 parameters like GMT2 and MWF.

Main Methods:

  • Implementation of a variable TR multiecho T2 sequence, linearly shortening TR from k-space center to edges.

Related Experiment Videos

  • Acquisition of data from six phantoms and 10 healthy volunteers using both constant and variable TR sequences.
  • Comparison of proton density, GMT2, and MWF values between the two acquisition methods.

    • Main Results:

    • Excellent agreement in proton density and GMT2 between constant and variable TR measurements in phantoms.
    • No significant differences in proton density or MWF were observed in brain structures between the two methods.
    • Average GMT2 across all structures showed no significant difference between constant and variable TR experiments.

    Conclusions:

    • The variable TR approach successfully reduces multiecho T2 acquisition time by over 20%.
    • This accelerated method maintains image resolution and does not significantly affect quantitative myelin imaging metrics (MWF, GMT2).
    • Variable TR offers a promising solution for efficient and accurate in vivo myelin water imaging.