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Related Experiment Video

Updated: Jul 15, 2026

Microscopy-based Assays for High-throughput Screening of Host Factors Involved in Brucella Infection of Hela Cells
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Published on: August 5, 2016

The liver in brucellosis.

Nikolaos Akritidis1, Michael Tzivras, Ioanna Delladetsima

  • 1Internal Medicine Department, General Hospital "G. Hatzikosta" of Ioannina, Ioannina, Greece.

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
|May 8, 2007
PubMed
Summary

Brucellosis, a zoonotic infection, commonly affects the liver, primarily through granuloma formation. This study reveals varied liver histopathology in Brucella melitensis infections, challenging previous beliefs.

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Area of Science:

  • Hepatology
  • Infectious Diseases
  • Pathology

Background:

  • Brucellosis frequently involves the liver, with presentations ranging from mild enzyme elevations to severe chronic disease.
  • Histopathological data on liver involvement in brucellosis is limited and often conflicting.
  • Brucellosis is a prevalent zoonotic infection with global distribution.

Purpose of the Study:

  • To investigate the histological patterns of liver involvement in patients with brucellosis.
  • To review current knowledge regarding hepatic manifestations of brucellosis.
  • To clarify the role of Brucella melitensis in liver pathology.

Main Methods:

  • Retrospective study of fourteen patients diagnosed with brucellosis caused by Brucella melitensis.
  • Analysis of liver biopsy specimens obtained at the time of diagnosis.
  • Review of existing literature on liver involvement in brucellosis.

Main Results:

  • Granuloma formation was observed in the liver parenchyma and portal spaces of all patients.
  • Other findings included cellular infiltration, giant cells, parenchymal necrosis, and Kupffer cell hyperplasia.
  • No significant correlations were found between liver involvement and epidemiological or clinical factors.

Conclusions:

  • The liver is consistently involved in Brucella melitensis infections, contrary to prior assumptions.
  • Granuloma formation is the most frequent histological pattern observed in hepatic brucellosis.
  • The contribution of brucellosis to liver fibrosis and cirrhosis requires further investigation.