Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Factors Affecting Respiration01:24

Factors Affecting Respiration

Respiration is a crucial physiological function involving exchanging oxygen (O2) and carbon dioxide (CO2) between an organism and its environment. Various factors can impact this essential process:
Acute Respiratory Failure-II01:21

Acute Respiratory Failure-II

Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
Oxygen Requirements and Growth Patterns01:29

Oxygen Requirements and Growth Patterns

Microorganisms exhibit diverse oxygen requirements and growth patterns driven by their metabolic strategies and environmental adaptations. Oxygen, while essential for many organisms, can also be toxic under certain conditions, shaping how microorganisms grow and survive.Oxygen Requirements of MicroorganismsMicroorganisms are classified based on their ability to use or tolerate oxygen:● Obligate aerobes like Mycobacterium tuberculosis need oxygen for energy production, as it serves as the...
Oxygen Transport in the Blood01:27

Oxygen Transport in the Blood

Hemoglobin (Hb) is a crucial molecule in the human body, consisting of four polypeptide chains, each bound to an iron-containing heme group. This unique structure enables hemoglobin to bind to oxygen, with each molecule capable of combining with four molecules of oxygen, leading to rapid and reversible oxygen loading. When fully loaded with oxygen, it is called oxyhemoglobin, while hemoglobin that has released oxygen is called reduced hemoglobin or deoxyhemoglobin. As hemoglobin binds oxygen,...
Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

High Intrinsic Aerobic Capacity Is Associated With a Distinct Epigenetic and Signaling Profile in the Aged Rat Brain.

Aging cell·2026
Same author

Intrinsic exercise capacity is associated with skeletal muscle clock gene and IGF-1 signaling in aged low- and high-running capacity rats.

Frontiers in physiology·2026
Same author

Olfactory bulb 6-OHDA neurotoxicity as a model of early cortical dysfunction.

Molecular and cellular biochemistry·2026
Same author

Trimethylamine N-oxide in exercise physiology: a gut microbiota-derived signal linking metabolic stress, redox balance and cardiometabolic health.

European journal of applied physiology·2026
Same author

Finite Element Analysis on the Effect of Activation Time on Cervical Spine Biomechanical Response During Pilot Ejection.

Applied bionics and biomechanics·2026
Same author

Muscle synergy asymmetry between the affected and unaffected limbs during the stance phase in unilateral flatfoot.

Journal of neuroengineering and rehabilitation·2026

Related Experiment Videos

High altitude and oxidative stress.

Agoston Dosek1, Hideko Ohno, Zoltan Acs

  • 1Institute of Sport Science, Faculty of Physical Education and Sport Science, Semmelweis University, Budapest, Hungary.

Respiratory Physiology & Neurobiology
|May 8, 2007
PubMed
Summary

High altitude exposure causes oxidative stress by increasing reactive oxygen and nitrogen species (RONS), damaging cells. Antioxidant vitamins may help mitigate this damage, especially during physical activity.

Related Experiment Videos

Area of Science:

  • Environmental Physiology
  • Oxidative Stress Biology

Background:

  • High altitude exposure is characterized by reduced oxygen pressure.
  • This condition can trigger oxidative/reductive stress and the generation of reactive oxygen and nitrogen species (RONS).
  • The extent of oxidative challenge correlates with the altitude's degree.

Purpose of the Study:

  • To investigate the mechanisms of oxidative damage at high altitude.
  • To explore the impact of high altitude on antioxidant systems.
  • To evaluate the role of antioxidant supplementation and physical activity.

Main Methods:

  • Review of RONS-generating systems activated at high altitude (mitochondrial electron transport chain, xanthine oxidase, nitric oxide synthase).
  • Assessment of high altitude effects on enzymatic and non-enzymatic antioxidant defenses.
  • Analysis of oxidative damage patterns compared to ischemia/reperfusion injury.

Main Results:

  • High altitude exposure activates multiple RONS-generating systems.
  • Both enzymatic and non-enzymatic antioxidant systems appear weakened at high altitude.
  • Physical exercise at high altitude intensifies oxidative stress.

Conclusions:

  • High altitude exposure induces significant oxidative stress and damage.
  • Antioxidant interventions, such as vitamin supplementation, may be beneficial.
  • Adaptation to high altitude oxidative stress is a prolonged process, and physical activity requires careful management.