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Panic Disorder

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Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

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Altered cingulate white matter connectivity in panic disorder patients.

Doug Hyun Han¹, Perry F Renshaw, Stephen R Dager

¹Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea.

Journal of Psychiatric Research

|May 8, 2007

Summary

Individuals with panic disorder show enhanced white matter connectivity in specific cingulate regions. These differences in the brain

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Area of Science:

Neuroimaging
Neuroscience
Psychiatry

Background:

Functional imaging suggests increased cingulate activation in panic disorder.
Understanding white matter connectivity is crucial for panic disorder research.

Purpose of the Study:

To investigate differences in white matter connectivity in cingulate regions between panic disorder patients and healthy controls.
To explore the relationship between white matter integrity and panic disorder severity.

Main Methods:

Diffusion tensor imaging (DTI) was used to assess fractional anisotropy (FA) values.
Structural white matter connectivity was examined in anterior and posterior cingulate regions.
24 panic disorder patients and 24 healthy controls participated.

Main Results:

Panic disorder subjects had significantly higher FA values in the left anterior and right posterior cingulate regions.
Increased FA values correlated positively with panic disorder symptom severity.
FA in the left anterior cingulate region showed correlations with cognitive test performance.

Conclusions:

Findings suggest enhanced white matter connectivity in specific cingulate regions in panic disorder.
These connectivity alterations may be implicated in the pathophysiology and symptoms of panic disorder.