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Relationship between metabolic syndrome (MS) and coronary heart disease (CHD) in an aged group

Qingwei Chen1, Ying Liu, Ying Yin

  • 1The Second Hospital of Chongqing Medical University, Department of Geriatrics, No. 74 Lin Jiang Road, Yuzhong District, 400010 Chongqing City, People's Republic of China. chenqwcq@yahoo.com.cn

Archives of Gerontology and Geriatrics
|May 8, 2007
PubMed

Insights

Metabolic syndrome (MS) significantly increases the risk of coronary heart disease (CHD) in elderly patients. MS presence predicts higher prevalence and severity of blocked coronary arteries, highlighting its role in cardiovascular disease progression.

Area of Science:

  • Cardiology
  • Metabolic Disorders
  • Geriatrics

Background:

  • Coronary heart disease (CHD) is a leading cause of mortality in the elderly.
  • Metabolic syndrome (MS) is a cluster of conditions that increase the risk of heart disease, stroke, and diabetes.
  • The relationship between MS and CHD in aged populations requires further investigation.

Purpose of the Study:

  • To investigate the association between metabolic syndrome (MS) and coronary heart disease (CHD) in patients aged 60 years and older.
  • To determine if MS predicts the prevalence and extent of CHD in the elderly.

Main Methods:

  • A cohort of 125 elderly patients (≥60 years) was studied, categorized into CHD and non-CHD groups, with subgroups for MS presence.
  • Clinical data including BMI, lipids, glucose, blood pressure, and uric acid were collected.
  • Selective coronary angiography was used to assess coronary vessel anatomy and disease severity.

Main Results:

  • The prevalence of MS was significantly higher in patients with CHD compared to those without (p<0.01).
  • Patients with both CHD and MS exhibited more severe disease, including multivessel disease and unstable lesions, requiring more revascularization procedures (p<0.05).
  • Spearman correlation and logistic regression analyses confirmed a direct correlation between MS and the prevalence and extent of CHD (p<0.01).

Conclusions:

  • Metabolic syndrome is a significant risk factor for coronary heart disease in the elderly.
  • MS is associated with increased prevalence, severity, and extent of coronary artery blockage.
  • MS can serve as a predictive marker for future CHD development and progression in older adults.

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