Related Experiment Video
Updated: Jul 15, 2026
Isolation and Differentiation of Stromal Vascular Cells to Beige/Brite Cells
Published on: March 28, 2013
QSAR analysis of PPAR-gamma agonists as anti-diabetic agents
Anshuman Dixit1, Anil K Saxena
1Medicinal and Process Chemistry Division, Central Drug Research Institute, Chattar Manzil Palace, MG Marg, Lucknow, Uttar Pradesh 226001, India.
Abstract:
QSAR studies have been performed on some PPAR-gamma agonists using TATA-BioSuite software to identify the essential structural and physico-chemical features for their PPAR-gamma agonistic activity. The 23 compounds were divided into training set of 18 and test set of five compounds using k-nearest neighbor (kNN) clustering. The steric, electronic and topological descriptors were found to have an important role in governing the variation in agonistic activity. The predicted activities by the developed models were in good accordance with the observed activities.
