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Symptomatic calcification of subureteral collagen ten years after injection

Kenneth G Nepple1, Matthew J Knudson, Christopher S Cooper

  • 1Division of Pediatric Urology, University of Iowa, Iowa City, Iowa 52242-1089, USA.

Urology
|May 8, 2007
PubMed

Insights

Bovine collagen injections for urinary issues can rarely lead to ureteral calcifications. Endoscopic removal of these calcifications is a feasible treatment option.

Area of Science:

  • Urology
  • Biomaterials

Background:

  • Bovine glutaraldehyde cross-linked collagen is an injectable bulking agent.
  • It is used to treat urinary incontinence and vesicoureteral reflux.

Observation:

  • A 16-year-old female presented with hematuria and back pain.
  • She had a history of left subureteral collagen injection at age 6.
  • A 7-mm calcification was passed, and CT revealed two 2-mm hyperdense foci in the left ureterovesical junction.

Findings:

  • Two submucosal calcifications were identified near the left ureteral orifice via cystoscopy.
  • These calcifications were successfully removed endoscopically.

Implications:

  • This case highlights a rare complication of collagen bulking agents.
  • Endoscopic management is a viable option for treating ureteral calcifications post-injection.

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