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[Primary brain lymphoma].

M Stein1, A Kuten, Y Ben-Arieh

  • 1Northern Israel Oncology Center, Haifa.

Harefuah
|July 1, 1991
PubMed
Summary
This summary is machine-generated.

Primary brain lymphoma (PBL) is rare in non-Hodgkin's lymphoma patients. Combined radiation and chemotherapy significantly improved survival for PBL patients, unlike radiotherapy alone.

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Area of Science:

  • Neurology
  • Oncology
  • Radiology

Context:

  • Non-Hodgkin's lymphoma (NHL) referrals between 1973-1989.
  • 1.4% of NHL patients presented with primary brain lymphoma (PBL).
  • One patient also had acquired immunodeficiency syndrome (AIDS).

Purpose:

  • To analyze the clinical presentation, diagnosis, and treatment outcomes of primary brain lymphoma (PBL).

Summary:

  • Ten patients with PBL (mean age 58) presented with symptoms of increased intracranial pressure.
  • Computerized tomography (CT) scans often revealed solitary lesions, commonly in the frontal lobe or cerebellum.
  • Diffuse, large cell, immunoblastic lymphoma was the most common subtype; diagnosis was via surgery or autopsy.

Impact:

  • Radiotherapy alone resulted in death within 3-5 months.
  • Combined radiation therapy and high-dose methotrexate-based chemotherapy led to long-term survival (15 and 48 months).