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Related Concept Videos

Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
Stages of Infection01:26

Stages of Infection

Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic01:26

Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic

Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies. Common...
Colonisation of Pathogens01:25

Colonisation of Pathogens

Pathogen colonization of host tissues is a critical step in the development of infectious diseases. Various pathogenic microorganisms, including bacteria, fungi, viruses, and protozoa, have evolved complex strategies to attach to, invade, and persist within host environments. These mechanisms enable pathogens to establish infections, evade immune responses, and resist antimicrobial treatments.Attachment to Host CellsIn bacteria, colonization typically begins with adherence to host epithelial...

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Updated: Jul 15, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

Small colony variant Staphylococcus aureus multiorgan infection.

Hemant Agarwal1, Rosemary Verrall, Sudha P Singh

  • 1Division of Pediatric Critical Care, Vanderbilt Children's Hospital, 2200 Children's Way, 5121 B Doctors Office Towers, Nashville, TN 37232, USA. hemantagarwal@hotmail.com

The Pediatric Infectious Disease Journal
|May 9, 2007
PubMed
Summary

Small colony variant Staphylococcus aureus causes persistent infections, often after antibiotic use. This report details a rare pediatric case of multiorgan infection without prior prolonged antibiotic treatment.

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Last Updated: Jul 15, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Pediatrics

Background:

  • Small colony variants (SCVs) of Staphylococcus aureus are associated with persistent and relapsing infections.
  • SCVs are typically identified following prolonged antibiotic therapy, complicating treatment outcomes.

Observation:

  • An unusual case of multiorgan infection involving Staphylococcus aureus SCVs in a pediatric patient is presented.
  • This case occurred in the absence of a history of prolonged antibiotic therapy.

Findings:

  • The study reports a rare presentation of Staphylococcus aureus SCV infection in a pediatric patient.
  • Multiorgan involvement was observed despite the lack of prolonged antibiotic exposure, challenging typical clinical presentations.

Implications:

  • This case highlights the potential for SCV Staphylococcus aureus to cause severe infections in pediatric patients even without prior antibiotic exposure.
  • Understanding atypical presentations of SCV infections is crucial for timely diagnosis and effective management in pediatric populations.
  • Further research may be needed to elucidate the mechanisms driving SCV formation and virulence in diverse clinical scenarios.