Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Malacoplakia of liver: a case report.

S J Robertson1, R B Higgins, C Powell

  • 1Department of Pathology, Ottawa General Hospital, Ontario, Canada.

Human Pathology
|December 1, 1991
PubMed
Summary

This is the first reported English case of liver malacoplakia, a rare condition. The immunosuppressed patient, due to systemic lupus erythematosus, showed late-stage malacoplakia at autopsy.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Efficacy of neuromuscular exercises to promote movement quality and reduce musculoskeletal injury during initial military training in Royal Navy recruits.

BMJ military health·2024
Same author

Achievement of Target Gain Larger than Unity in an Inertial Fusion Experiment.

Physical review letters·2024
Same author

Impact of the COVID-19 Pandemic on Outcomes for Patients with Lung Cancer Receiving Curative-intent Radiotherapy in the UK.

Clinical oncology (Royal College of Radiologists (Great Britain))·2023
Same author

Assessment of the Implementation of Lung Cancer Consensus Statements From the Royal College of Radiologists in 2021; Progress and Barriers.

Clinical oncology (Royal College of Radiologists (Great Britain))·2022
Same author

Implementing Genomic Testing for Lung Cancer Into Routine Clinical Practice - The Welsh Experience.

Clinical oncology (Royal College of Radiologists (Great Britain))·2022
Same author

Lawson Criterion for Ignition Exceeded in an Inertial Fusion Experiment.

Physical review letters·2022

Area of Science:

  • * Hepatology
  • * Immunopathology
  • * Rare Diseases

Background:

  • * Malacoplakia is a rare granulomatous disease typically affecting the urinary tract.
  • * Systemic lupus erythematosus (SLE) is an autoimmune condition often managed with immunosuppressive therapy.
  • * Immunosuppression is a known risk factor for opportunistic infections and unusual disease presentations.

Observation:

  • * A patient with a history of SLE on long-term steroid therapy presented with an uncharacterized illness.
  • * Diagnostic investigations were pursued, leading to the eventual identification of liver involvement.
  • * The clinical course was protracted, spanning 18 months from initial presentation to death.

Findings:

  • * Histopathological examination of the liver revealed characteristic features of malacoplakia.
  • * This represents the first documented instance of malacoplakia specifically affecting the liver in the English medical literature.
  • * Autopsy findings confirmed the late or fibrous stage of malacoplakia in the liver tissue.

Implications:

  • * This case expands the known organ manifestations of malacoplakia.
  • * It highlights the importance of considering malacoplakia in immunosuppressed patients with unexplained organ dysfunction.
  • * Further research may be warranted to understand the pathogenesis of hepatic malacoplakia.

Related Experiment Videos