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Published on: June 4, 2021
Ultrasound-enhanced Thrombolysis
1Midwest Vascular Institute of Illinois, Downers Grove, Illinois 60515, USA. Midwestvascular@aol.com
Summary
Ultrasound-enhanced thrombolysis effectively treats arterial and venous clots, achieving high success rates in acute and chronic cases. This method offers a faster lysis time compared to conventional treatments.
Area of Science:
- Vascular Surgery
- Interventional Radiology
- Cardiovascular Medicine
Background:
- Thrombosis, encompassing both arterial and venous occlusions, presents a significant clinical challenge.
- Conventional thrombolysis can be time-consuming and may have limitations in achieving complete clot lysis.
Purpose of the Study:
- To evaluate the clinical efficacy and outcomes of ultrasound-enhanced thrombolytic therapy.
- To assess the treatment of both acute and chronic arterial and venous thromboses using this technique.
Main Methods:
- A single-center study involving 33 patients with 36 occlusions treated between January 2005 and June 2006.
- Ultrasound-enhanced thrombolytic therapy utilized urokinase infusion via an infusion catheter after diagnostic angiography.
- Dosage ranged from 80,000-120,000 IU/h for urokinase infusion.
Main Results:
- High technical success rates were observed: 96% for arterial occlusions and 83% for venous occlusions.
- Complete lysis was achieved in the majority of cases, with average lysis times of 16.4 hours for arterial and 21.2 hours for deep vein thrombosis.
- Two cases of chronic occlusions (superficial femoral artery and iliac vein) were refractory to therapy.
Conclusions:
- Ultrasound-enhanced thrombolysis is a successful treatment modality for both acute and chronic arterial and venous thromboses.
- This technique demonstrates a high success rate and potentially shorter treatment times compared to conventional thrombolysis.
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