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Updated: Jul 15, 2026
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Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study
Published on: August 15, 2025
Surgical outcome in tuberous sclerosis complex: a multicenter survey
Deepak Madhavan1, Sarah Schaffer, Alexei Yankovsky
1Comprehensive Epilepsy Center, Department of Neurology, NYU Medical Center, 403 East 34th Street, New York, NY 10016, U.S.A. madhad01@med.nyu.edu
Epilepsia
|May 9, 2007
Summary
Younger age at seizure onset, infantile spasms, bilateral interictal focality, and no residual tubers predict poorer outcomes after epilepsy surgery in Tuberous Sclerosis Complex (TSC). These factors are crucial for surgical success prediction.
Area of Science:
- Neurology
- Neurosurgery
- Genetics
Background:
- Tuberous Sclerosis Complex (TSC) is a genetic disorder.
- Epilepsy is a common and challenging manifestation of TSC.
- Surgical interventions are employed to manage intractable epilepsy in TSC patients.
Purpose of the Study:
- To identify predictors of postoperative outcomes in TSC patients undergoing epilepsy surgery.
- To elucidate factors associated with successful versus unsuccessful seizure relief.
Main Methods:
- Retrospective analysis of data from 70 subjects with TSC.
- Inclusion of patients who underwent surgery for epilepsy relief.
- Statistical analysis to determine associations between clinical/imaging variables and surgical outcomes.
Main Results:
- Younger age at seizure onset, history of infantile spasms, bilateral interictal focality, and absence of residual postoperative tubers were significantly associated with poorer outcomes (p < 0.01).
- Ictal multifocality, mental retardation, and discordant EEG/MRI data showed non-significant negative trends.
Conclusions:
- Preoperative factors such as age at onset, seizure history, and EEG/MRI findings are critical for predicting epilepsy surgery outcomes in TSC.
- Identifying these predictors can aid in patient selection and management strategies for TSC-associated epilepsy.
