Related Experiment Video
Updated: Jul 15, 2026

Generation of Genetically Modified Mice through the Microinjection of Oocytes
Published on: June 15, 2017
Mammalian specific mouse genes are evolving faster than mouse genes conserved across other eukaryotic lineages
Iti Chaturvedi1, Mya Myintzu Hlaing, Lim Chu Sing
1Advanced design and modeling lab, Affiliated staff BioInformatics Research Centre, Nanyang Technological University, Singapore.
Abstract:
Positive selection is usually considered in the context of a higher rate of substitutions in non-synonymous as compared to synonymous sites in complete coding sequences of genes or individual positions. We show that genes conserved in eukaryota, coelomata, and bilateria, that is, proteins that arose earlier in evolution as compared to mammalia specific genes evolve slowly and are subjected to negative selection. This finding supports the notion that evolutionary rates progressively diminish with the age of a gene. The data suggests that in both intron-containing and intronless genes synonymous sites may be subject to some degree of selection that is indicative of a relative acceleration of amino-acid substitution, which could be due to a relaxation of functional constraints and/or directional selection.
Related Concept Videos
Gene Evolution - Fast or Slow?
In contrast, regions which code...
Gene Evolution - Fast or Slow?
In contrast, regions which code...
Multi-species Conserved Sequences
Although the genome of each species varies greatly from each other, a few sequences are highly conserved. Such conserved DNA...
Mouse Models of Cancer Study
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
Synteny and Evolution
Around 80 million years ago, the human and mice lineages diverged from the common ancestor. During the course of evolution, the ancestral chromosome underwent...
In-vitro Mutagenesis

