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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

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Related Experiment Video

Updated: Jul 15, 2026

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports
07:44

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports

Published on: November 28, 2019

Targeting the tumor microenvironment.

Paraic A Kenny1, Genee Y Lee, Mina J Bissell

  • 1Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA. pakenny@lbl.gov

Frontiers in Bioscience : a Journal and Virtual Library
|May 9, 2007
PubMed
Summary

Cancer treatment is evolving beyond targeting tumor cells alone. Emerging research highlights the crucial role of the tumor microenvironment, revealing new therapeutic strategies and drug targets for improved cancer therapies.

Related Experiment Videos

Last Updated: Jul 15, 2026

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports
07:44

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports

Published on: November 28, 2019

Area of Science:

  • Oncology
  • Cancer Biology
  • Drug Discovery

Background:

  • Cancer remains a significant challenge despite advances in treatment.
  • The tumor microenvironment, comprising stromal cells and signaling pathways, plays a critical role in cancer progression.
  • Targeting tumor epithelial cells alone is insufficient for effective cancer therapy.

Purpose of the Study:

  • To explore the intricate interactions between tumor epithelial cells and the surrounding stroma.
  • To identify and review "druggable" targets and processes within the tumor microenvironment.
  • To discuss therapeutic approaches aimed at disrupting these tumor-stroma interactions.

Main Methods:

  • Review of current scientific literature on tumor microenvironment.
  • Analysis of emerging therapeutic targets and drug development pipelines.
  • Discussion of approved and investigational agents targeting microenvironmental components.

Main Results:

  • Established synergy between tumor epithelium and stroma necessitates a broader therapeutic approach.
  • Several key components and processes within the tumor microenvironment are identified as potential drug targets.
  • Existing drugs (e.g., targeting VEGF, aromatase) demonstrate the viability of targeting the microenvironment.

Conclusions:

  • Disrupting the dialogue between tumor cells and their microenvironment offers promising therapeutic avenues.
  • Further research into tumor microenvironment interactions will yield novel strategies for cancer treatment.
  • Targeting the tumor microenvironment represents a critical frontier in developing more effective cancer therapies.