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Related Experiment Video

Updated: Jul 15, 2026

Expression, Purification, and Liposome Binding of Budding Yeast SNX-BAR Heterodimers

Expression, Purification, and Liposome Binding of Budding Yeast SNX-BAR Heterodimers

Published on: December 6, 2019

Retromer and sorting nexins in development.

Marcel Verges¹

¹Laboratory of Epithelial Cell Biology, Centro de Investigacion Principe Felipe, Valencia, Spain. mverges@cipf.es

Frontiers in Bioscience : a Journal and Virtual Library

|May 9, 2007

Summary

Sorting nexins, particularly the retromer complex, are crucial for intracellular trafficking and receptor signaling. Recent studies highlight retromer

Area of Science:

Cell Biology
Molecular Biology
Biochemistry

Background:

Intracellular trafficking and signaling pathways share common molecular machinery.
Proper trafficking is essential for accurate signaling, exemplified by sustained signaling of endocytosed receptors.
Sorting nexins, especially the retromer complex, play a key role in endosomal receptor fate.

Purpose of the Study:

To review recent findings on the role of retromer in intracellular trafficking and signaling.
To discuss the implications of retromer's function in various model organisms.

Main Methods:

Review of existing literature on sorting nexins and retromer.
Analysis of data from yeast, mammalian cell cultures, mice, and Caenorhabditis elegans.
Focus on receptor trafficking and signaling mechanisms.

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Osmotic Avoidance in Caenorhabditis elegans: Synaptic Function of Two Genes, Orthologues of Human NRXN1 and NLGN1, as Candidates for Autism

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Osmotic Avoidance in Caenorhabditis elegans: Synaptic Function of Two Genes, Orthologues of Human NRXN1 and NLGN1, as Candidates for Autism

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Main Results:

Retromer mediates endosome-to-Golgi retrieval of receptors in yeast and higher eukaryotes.
Retromer is essential for embryogenesis in model organisms like mice and C. elegans.
Sorting nexins are integral to controlling receptor fate at the endosome.

Conclusions:

The retromer complex is vital for coordinating intracellular trafficking and receptor signaling.
Retromer's function is conserved across species and critical for development.
Further research into retromer's implications is warranted.